Factor XI Deficiency in dogs

Species: Dog
Condition: Factor XI Deficiency
Organ System: Cardiovascular

Factor XI deficiency is a bleeding disorder in which the animal has a deficiency in Factor XI, a protein that is necessary for the clotting of blood, resulting in slower than normal clotting of blood. Affected dogs exhibit excessive bleeding especially after surgery or trauma, delayed healing and spontaneous hematoma formation up to 3-4 days later. Kerry Blue Terriers, Great Pyrenees, and English Springer Spaniels are predisposed. The disease is inherited; heterozygotes for the condition have 15-50% of the normal activity of Factor XI and are asymptomatic while homozygotes only have 10% to <20% activity. During acute bleeding, whole blood or fresh frozen cryoprecipitate plasma can be given to affected dogs. Most affected dogs are clinically normal between hemorrhagic crises.[/vc_column_text][/tab][tab title="Breeds Affected" id="1429595557-2-77"][vc_column_text]Breeds exposed to Factor XI Deficiency – Research Reference
Basset Hound Cross – University of Sydney (LIDA Dog Disease Database)
“Miniature Dachshund Cross – (Brodey & Kelly 1968
Alaskan Malamute Cross – University of Sydney (LIDA Dog Disease Database)
Beagle Cross – University of Sydney (LIDA Dog Disease Database)
“Miniature Dachshund- Long Haired Cross – (Brodey & Kelly 1968
“Miniature Dachshund – Wire Haired Cross – (Brodey & Kelly 1968
“Miniature Dachshund – Smooth Haired Cross – (Brodey & Kelly 1968
Alaskan Malamute – University of Sydney (LIDA Dog Disease Database)
Basset Hound – University of Sydney (LIDA Dog Disease Database)
Beagle – University of Sydney (LIDA Dog Disease Database)
“Bernese Mountain Dog Cross – (Brodey & Kelly 1968
“Bernese Mountain Dog – (Brodey & Kelly 1968
“Miniature Dachshund – (Brodey & Kelly 1968
“Miniature Dachshund – Smooth Haired – (Brodey & Kelly 1968
“Miniature Dachshund – Wire Haired – (Brodey & Kelly 1968
“Miniature Dachshund- Long Haired – (Brodey & Kelly 1968

Disease Author
Dr Merliza Cabriles, Professor of Veterinary Medicine

To learn more about Factor XI Deficiency or any other condition we invite you to search this website. Even better, pick up the phone and call your vet. Your vet knows your pet better than anyone else and is a fountain of information.